Assessing the suitability of summary data for two-sample Mendelian randomization analyses using MR-Egger regression: the role of the I2 statistic

Bowden, Jack; Del Greco M, Fabiola; Minelli, Cosetta; Davey Smith, George; A. Sheehan, Nuala; R. Thompson, John

doi:10.1093/ije/dyw220

Public

Assessing the suitability of summary data for two-sample Mendelian randomization analyses using MR-Egger regression: the role of the I2 statistic

Published in International Journal of Epidemiology • Sep 11, 2016

Authors:

Jack Bowden

Fabiola Del Greco M

Cosetta Minelli

Abstract

Background: : MR-Egger regression has recently been proposed as a method for Mendelian randomization (MR) analyses incorporating summary data estimates of causal effect from multiple individual variants, which is robust to invalid instruments. It can be used to test for directional pleiotropy and pr...

Subject

Mendelian randomization

Regression

Statistic

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