Prevalence of mutations in LEP, LEPR, and MC4R genes in individuals with severe obesity

Paolini, Barbara; Enrico Maltese, Paolo; Del Ciondolo, Irene; Tavian, Daniela; Missaglia, Sara; Ciuoli, Cristina; Zuntini, Monia; Cecchin, S; Bertelli, Matteo; Pompucci, G.

doi:10.4238/gmr.15038718

Public

Prevalence of mutations in LEP, LEPR, and MC4R genes in individuals with severe obesity

Published in Genetics and Molecular Research • Jan 1, 2016

Authors:

Barbara Paolini

Paolo Enrico Maltese

Irene Del Ciondolo

Abstract

, early onset and a family history of being overweight. Candidate genes were screened by direct sequence analysis to search for rare genetic variations. The common LEP -2548 G/A polymorphism was also evaluated for its influence on the BMI (in obesity patients) and for obesity risk, using a case-cont...

Subject

Melanocortin 4 receptor

Obesity

Leptin

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