Replication of human noroviruses in stem cell–derived human enteroids

Ettayebi, Khalil; E. Crawford, Sue; Murakami, Kosuke; R. Broughman, James; C. Karandikar, Umesh; R. Tenge, Victoria; H. Neill, Frederick; E. Blutt, Sarah; Zeng, Xi‐Lei; Qu, Lin; Kou, Baijun; R. Opekun, Antone; G. Burrin, Douglas; Y. Graham, David; Ramani, Sasirekha; L. Atmar, Robert; K. Estes, Mary

doi:10.1126/science.aaf5211

Public

Replication of human noroviruses in stem cell–derived human enteroids

Published in Science • Aug 25, 2016

Authors:

Khalil Ettayebi

Sue E. Crawford

Kosuke Murakami

Abstract

The major barrier to research and development of effective interventions for human noroviruses (HuNoVs) has been the lack of a robust and reproducible in vitro cultivation system. HuNoVs are the leading cause of gastroenteritis worldwide. We report the successful cultivation of multiple HuNoV strain...

Subject

Infectivity

Biology

Intestinal epithelium

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