Intra-articular injection of two different doses of autologous bone marrow mesenchymal stem cells versus hyaluronic acid in the treatment of knee osteoarthritis: multicenter randomized controlled clinical trial (phase I/II)

María Lamo-Espinosa, José; Mora, Gonzalo; F. Blanco, Juan; Granero‐Moltó, Froilán; M. Núñez‐Córdoba, Jorge; Sánchez-Echenique, Carmen; M. Bondía, J.; Dámaso Aquerreta, Jesús; J. Andreu, Enrique; Ornilla, Enrique; M. Villarón, Eva; Valentí-Azcárate, Andrés; Sánchez‐Guijo, Fermín; del Cañizo, M.C.; Ramón Valentí-Nin, Juan; Prósper, Felipe

doi:10.1186/s12967-016-0998-2

Public

Intra-articular injection of two different doses of autologous bone marrow mesenchymal stem cells versus hyaluronic acid in the treatment of knee osteoarthritis: multicenter randomized controlled clinical trial (phase I/II)

Published in Journal of Translational Medicine • Aug 26, 2016

Authors:

José María Lamo-Espinosa

Gonzalo Mora

Juan F. Blanco

Abstract

BACKGROUND: Mesenchymal stromal cells are a promising option to treat knee osteoarthritis. Their safety and usefulness must be confirmed and the optimal dose established. We tested increasing doses of bone marrow mesenchymal stromal cells (BM-MSCs) in combination with hyaluronic acid in a randomized...

Subject

Hyaluronic acid

Osteoarthritis

Medicine

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