An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation

Hannon, Eilís; Dempster, Emma; Viana, Joana; Burrage, Joe; R. Smith, Adam; I. MacDonald, Ruby; St Clair, David; Mustard, Colette; Breen, Gerome; Therman, Sebastian; Kaprio, Jaakko; Toulopoulou, Timothea; E. Hulshoff Pol, Hilleke; M. Bohlken, Marc; S. Kahn, René; Nenadić, Igor; M. Hultman, Christina; Murray, Robin; Collier, David; Bass, Nick; Gurling, Hugh; McQuillin, Andrew; C. Schalkwyk, Leonard; Mill, Jonathan

doi:10.1186/s13059-016-1041-x

Public

An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation

Published in Genome biology • Aug 23, 2016

Authors:

Eilís Hannon

Emma Dempster

Joana Viana

Abstract

BACKGROUND: Schizophrenia is a highly heritable, neuropsychiatric disorder characterized by episodic psychosis and altered cognitive function. Despite success in identifying genetic variants associated with schizophrenia, there remains uncertainty about the causal genes involved in disease pathogene...

Subject

Biology

DNA methylation

Epigenetics

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