Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans

M. Holdt, Lesca; Stahringer, Anika; Sass, Kristina; Pichler, Garwin; A. Kulak, Nils; Wilfert, Wolfgang; Kohlmaier, Alexander; Herbst, Andreas; H. Northoff, Bernd; Nicolaou, Alexandros; Gäbel, Gábor; Beutner, Frank; Scholz, Markus; Thiery, Joachim; Musunuru, Kiran; Krohn, Knut; Mann, Matthias; Teupser, Daniel

doi:10.1038/ncomms12429

Public

Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans

Published in Nature Communications • Aug 19, 2016

Authors:

Lesca M. Holdt

Anika Stahringer

Kristina Sass

Abstract

Circular RNAs (circRNAs) are broadly expressed in eukaryotic cells, but their molecular mechanism in human disease remains obscure. Here we show that circular antisense non-coding RNA in the INK4 locus (circANRIL), which is transcribed at a locus of atherosclerotic cardiovascular disease on chromoso...

Subject

Non-coding RNA

Ribosome biogenesis

Circular RNA

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