Single-cell RNA-seq reveals novel regulators of human embryonic stem cell differentiation to definitive endoderm

Chu, Li‐Fang; Leng, Ning; Zhang, Jue; Hou, Zhonggang; Mamott, Daniel; Vereide, David; Choi, Jeea; Kendziorski, Christina; Stewart, Ron; A. Thomson, James

doi:10.1186/s13059-016-1033-x

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Single-cell RNA-seq reveals novel regulators of human embryonic stem cell differentiation to definitive endoderm

Published in Genome biology • Aug 17, 2016

Authors:

Li‐Fang Chu

Ning Leng

Jue Zhang

Abstract

BACKGROUND: Human pluripotent stem cells offer the best available model to study the underlying cellular and molecular mechanisms of human embryonic lineage specification. However, it is not fully understood how individual stem cells exit the pluripotent state and transition towards their respective...

Subject

Biology

Embryonic stem cell

Induced pluripotent stem cell

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