Osteoclast-derived microRNA-containing exosomes selectively inhibit osteoblast activity

Sun, Weijia; Zhao, Chenyang; Li, Yuheng; Li, Yuheng; Wang, Liang; Nie, Guangjun; Peng, Jiang; Wang, Aiyuan; Zhang, Pengfei; Tian, Weiming; Li, Qi; Song, Jinping; Wang, Cheng; Xu, Xiaolong; Tian, Yanhua; Zhao, Dingsheng; Xu, Zi; Zhong, Guohui; Han, Bingxing; Ling, Shukuan; Chang, Yan-Zhong; Li, Yingxian; Li, Yingxian

doi:10.1038/celldisc.2016.15

Public

Osteoclast-derived microRNA-containing exosomes selectively inhibit osteoblast activity

Published in Cell Discovery • May 31, 2016

Authors:

Weijia Sun

Chenyang Zhao

Yuheng Li

Abstract

MicroRNAs have an important role in bone homeostasis. However, the detailed mechanism of microRNA-mediated intercellular communication between bone cells remains elusive. Here, we report that osteoclasts secrete microRNA-enriched exosomes, by which miR-214 is transferred into osteoblasts to inhibit ...

Subject

Microvesicles

Osteoblast

Osteoclast

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!