Comparison of MAPIE versus MAP in patients with a poor response to preoperative chemotherapy for newly diagnosed high-grade osteosarcoma (EURAMOS-1): an open-label, international, randomised controlled trial

Marina, Neyssa; Smeland, Sigbjørn; Bielack, Stefan; L. Bernstein, Mark; Jovic, Gordana; Krailo, Mark; Hook, Jane; Arndt, Carola; van den Berg, Henk; Brennan, Bernadette; Brichard, Bénédicte; Brown, Ken; Butterfaß‐Bahloul, Trude; Calaminus, Gabriele; E. Daldrup‐Link, Heike; Eriksson, Mikael; C. Gebhardt, Mark; Gelderblom, Hans; Gerß, Joachim; E. Goldsby, Robert; M. Goorin, Allen; Görlick, Richard; E. Grier, Holcombe; Hale, Juliet; Sundby Hall, Kirsten; Hardes, Jendrik; S. Hawkins, Douglas; Helmke, K.; C.W. Hogendoorn, Pancras; S. Isakoff, Michael; A. Janeway, Katherine; Jürgens, Heribert; Kager, Leo; Kühne, Thomas; C. Lau, Ching; J. Leavey, Patrick; L. Lessnick, Stephen; Mascarenhas, Leo; A. Meyers, Paul; Mottl, Hubert; Nathrath, Michaela; Pápai, Zsuzsanna; Lor Randall, R.; Reichardt, Peter; Renard, Marleen; Safwat, Akmal; L. Schwartz, Cindy; C.G. Stevens, Michaël; J. Strauss, Sandra; A. Teot, Lisa; Werner, Mathias; R. Sydes, Matthew; Whelan, Jeremy

doi:10.1016/s1470-2045(16)30214-5

Public

Comparison of MAPIE versus MAP in patients with a poor response to preoperative chemotherapy for newly diagnosed high-grade osteosarcoma (EURAMOS-1): an open-label, international, randomised controlled trial

Published in The Lancet Oncology • Aug 31, 2016

Authors:

Neyssa Marina

Sigbjørn Smeland

Stefan Bielack

Abstract

Background We designed the EURAMOS-1 trial to investigate whether intensified postoperative chemotherapy for patients whose tumour showed a poor response to preoperative chemotherapy (≥10% viable tumour) improved event-free survival in patients with high-grade osteosarcoma. Methods EURAMOS-1 was an ...

Subject

Osteosarcoma

Open label

Medicine

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