Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination

V. Pageon, Sophie; Tabarin, Thibault; Yamamoto, Yui; Ma, Yuanqing; R. Nicovich, Philip; S. Bridgeman, John; Cohnen, André; Benzing, Carola; Gao, Yijun; D. Crowther, Michael; Tungatt, Katie; Dolton, Garry; K. Sewell, Andrew; A. Price, David; Acuto, Oreste; G. Parton, Robert; Justin Gooding, J.; Rossy, Jérémie; Rossjohn, Jamie; Gaus, Katharina

doi:10.1073/pnas.1607436113

Public

Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination

Published in Proceedings of the National Academy of Sciences • Aug 29, 2016

Authors:

Sophie V. Pageon

Thibault Tabarin

Yui Yamamoto

Abstract

Antigen recognition by the T-cell receptor (TCR) is a hallmark of the adaptive immune system. When the TCR engages a peptide bound to the restricting major histocompatibility complex molecule (pMHC), it transmits a signal via the associated CD3 complex. How the extracellular antigen recognition even...

Subject

Nanoclusters

Receptor

SIGNAL (programming language)

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