Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen

Xu, Miao; M. Lee, Emily; Wen, Zhexing; Cheng, Yichen; Huang, Wei-Kai; Qian, Xuyu; TCW, Julia; Kouznetsova, Jennifer; C. Ogden, Sarah; Hammack, Christy; Jacob, Fadi; Nguyen, Ha; Itkin, Misha; Hanna, Catherine; Shinn, Paul; A. Allen, Chase; Michael, Sam; Simeonov, Anton; Huang, Wenwei; M. Christian, Kimberly; Goate, Alison; Brennand, Kristen; Huang, Ruili; Xia, Menghang; Ming, Guo‐li; Zheng, Wei; Song, Hongjun; Tang, Hengli

doi:10.1038/nm.4184

Public

Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen

Published in Nature Medicine • Aug 29, 2016

Authors:

Miao Xu

Emily M. Lee

Zhexing Wen

Abstract

In response to the current global health emergency posed by the Zika virus (ZIKV) outbreak and its link to microcephaly and other neurological conditions, we performed a drug repurposing screen of ∼6,000 compounds that included approved drugs, clinical trial drug candidates and pharmacologically act...

Subject

Zika virus

Drug repositioning

Repurposing

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