Association of RNA Biosignatures With Bacterial Infections in Febrile Infants Aged 60 Days or Younger

Mahajan, Prashant; Kuppermann, Nathan; Mejías, Asunción; M. Suárez, Nicolás; Chaussabel, Damien; Charles Casper, T.; Smith, B.; R. Alpern, Elizabeth; Anders, Jennifer; M. Atabaki, Shireen; E. Bennett, Jonathan; Blumberg, Stephen; K. Bonsu, Bema; Borgialli, Dominic; Brayer, Anne; R. Browne, Lorin; M. Cohen, Daniel; F. Crain, Ellen; T. Cruz, Andrea; S. Dayan, Peter; Gattu, Rajender; A. Greenberg, Richard; D. Hoyle, John; M. Jaffe, David; A. Levine, Deborah; Lillis, Kathleen; G. Linakis, James; T. Muenzer, Jared; E. Nigrovic, Lise; C. Powell, Elizabeth; J. Rogers, Alexander; Roosevelt, Genie; M. Ruddy, Richard; Saunders, Mary; G. Tunik, Michael; Tzimenatos, Leah; Vitale, elissa; Dean, Jurrien; Ramilo, Octavio

doi:10.1001/jama.2016.9207

Public

Association of RNA Biosignatures With Bacterial Infections in Febrile Infants Aged 60 Days or Younger

Published in JAMA • Aug 23, 2016

Authors:

Prashant Mahajan

Nathan Kuppermann

Asunción Mejías

Abstract

IMPORTANCE: Young febrile infants are at substantial risk of serious bacterial infections; however, the current culture-based diagnosis has limitations. Analysis of host expression patterns ("RNA biosignatures") in response to infections may provide an alternative diagnostic approach. OBJECTIVE: To ...

Subject

Medicine

Bacteremia

Observational study

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