Consistent View of Polypeptide Chain Expansion in Chemical Denaturants from Multiple Experimental Methods

Borgia, Alessandro; Zheng, Wenwei; Buholzer, Karin; B. Borgia, Madeleine; Schüler, Anja; Hofmann, Hagen; Soranno, Andrea; Nettels, Daniel; Gast, Klaus; Grishaev, Alexander; B. Best, Robert; Schuler, Benjamin

doi:10.1021/jacs.6b05917

Public

Consistent View of Polypeptide Chain Expansion in Chemical Denaturants from Multiple Experimental Methods

Published in Journal of the American Chemical Society • Sep 1, 2016

Authors:

Alessandro Borgia

Wenwei Zheng

Karin Buholzer

Abstract

There has been a long-standing controversy regarding the effect of chemical denaturants on the dimensions of unfolded and intrinsically disordered proteins: A wide range of experimental techniques suggest that polypeptide chains expand with increasing denaturant concentration, but several studies us...

Subject

Small-angle X-ray scattering

Chemistry

Radius of gyration

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