Targeting eIF5A Hypusination Prevents Anoxic Cell Death through Mitochondrial Silencing and Improves Kidney Transplant Outcome.

N, Melis; I, Rubera; M, Cougnon; S, Giraud; B, Mograbi; A, Belaid; DF, Pisani; SM, Huber; S, Lacas-Gervais; K, Fragaki; N, Blondeau; P, Vigne; C, Frelin; T, Hauet; C, Duranton; M, Tauc

doi:10.1681/asn.2016010012

Public

Targeting eIF5A Hypusination Prevents Anoxic Cell Death through Mitochondrial Silencing and Improves Kidney Transplant Outcome.

Shared by NobleBlocks on Sep 9, 2016 • 12:00 AM UTC

Authors:

Melis N

Rubera I

Cougnon M

Abstract

The eukaryotic initiation factor 5A (eIF5A), which is highly conserved throughout evolution, has the unique characteristic of post-translational activation through hypusination. This modification is catalyzed by two enzymatic steps involving deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxylas...

Subject

Hypoxia

Cell survival

Ischemia

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