Targeting eIF5A Hypusination Prevents Anoxic Cell Death through Mitochondrial Silencing and Improves Kidney Transplant Outcome

Mélis, Nicolas; Rubera, Isabelle; Cougnon, Marc; Giraud, Sébastien; Mograbi, Baharia; Belaïd, Amine; F. Pisani, Didier; M. Huber, Stephan; Lacas‐Gervais, Sandra; Fragaki, Konstantina; Blondeau, Nicolas; Vigne, Paul; Frelin, Christian; Hauet, Thierry; Duranton, Christophe; Tauc, Michel

doi:10.1681/asn.2016010012

Public

Targeting eIF5A Hypusination Prevents Anoxic Cell Death through Mitochondrial Silencing and Improves Kidney Transplant Outcome

Published in Journal of the American Society of Nephrology • Sep 9, 2016

Authors:

Nicolas Mélis

Isabelle Rubera

Marc Cougnon

Abstract

The eukaryotic initiation factor 5A (eIF5A), which is highly conserved throughout evolution, has the unique characteristic of post-translational activation through hypusination. This modification is catalyzed by two enzymatic steps involving deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxylas...

Subject

DHPS

Mitochondrion

Cell biology

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