The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

Ehret, Georg; Ferreira, Teresa; I. Chasman, Daniel; Jackson, Anne; M. Schmidt, Ellen; Johnson, Toby; Þorleifsson, Guðmar; Luan, Jian’an; A Donnelly, Louise; Kanoni, Stavroula; Petersen, Ann-Kristin; Pihur, Vasyl; J. Strawbridge, Rona; Shungin, Dmitry; Hughes, Maria; Meirelles, Osorio; Kaakinen, Marika; Bouatia‐Naji, Nabila; Kristiansson, Kati; Shah, Sonia; E. Kleber, Marcus; Guo, Xiuqing; Lyytikäinen, Leo‐Pekka; Fava, Cristiano; Eriksson, Niclas; M. Nolte, Ilja; K. E. Magnusson, Patrik; Salfati, Elias; S. Rallidis, Lοukianos; Theusch, Elizabeth; J. Smith, Andrew; Folkersen, Lasse; Witkowska, Kate; H. Pers, Tune; Joehanes, Roby; K. Kim, Stuart; Lataniotis, Lazaros; Jansen, Rick; D. Johnson, Andrew; R. Warren, Helen; Jin Kim, Young; Zhao, Wei; Wu, Ying; O. Tayo, Bamidele; Bochud, Murielle; Absher, Devin; S. Adair, Linda; Amin, Najaf; E. Arking, Dan; Axelsson, Tomas; Baldassarre, Damiano; Balkau, Beverley; Bandinelli, Stefania; R. Barnes, Michael; Barroso, Inês; Bevan, Steve; C Bis, Joshua; Björnsdóttir, Gyða; Boehnke, Michael; Boerwinkle, Eric; L. Bonnycastle, Lori; I. Boomsma, Dorret; R. Bornstein, Stefan; J. Brown, Morris; Burnier, Michel; Cabrera, Claudia; C. Chambers, John; Chang, I‐Shou; Cheng, Ching‐Yu; S. Chines, Peter; Chung, Ren-Hua; S. Collins, Francis; Connell, John; Döring, Angela; Dallongeville, Jean; Danesh, John; dé Fairé, Ulf; Delgado, Graciela; F. Dominiczak, Anna; S. F. Doney, Alex; Drenos, Fotios; Edkins, Sarah; D. Eicher, John; Elosúa, Roberto; Enroth, Stefan; Erdmann, Jeanette; Eriksson, Per; Esko, Tõnu; Εvangelou, Εvangelos; Evans, Alun; Fall, Tove; Farrall, Martin; F. Felix, Janine; Ferrières, Jean; Ferrucci, Luigi; Fornage, Myriam; Forrester, Terrence; Franceschini, Nora; H Franco Duran, Oscar; Franco‐Cereceda, Anders; M. Fraser, Ross; K. Ganesh, Santhi; Gao, He; Gertow, Karl; Gianfagna, Francesco; Gigante, Bruna; Giulianini, Franco; Goel, Anuj; H. Goodall, Alison; O Goodarzi, Mark; Gorski, Mathias; Gräßler, Jürgen; J. Groves, Christopher; Guðnason, Vilmundur; Gyllensten, Ulf; Hallmans, Göran; Hartikainen, Anna-Liisa; Hassinen, Maija; S. Havulinna, Aki; Hayward, Caroline; Herçberg, Serge; Herzig, Karl-Heinz; A. Hicks, Andrew; D. Hingorani, Aroon; N. Hirschhorn, Joel; Hofman, Albert; Holmen, Jostein; L. Holmen, Oddgeir; Hottenga, Jouke‐Jan; Howard, Phil; A. Hsiung, Chao; C. Hunt, Steven; Arfan Ikram, M.; Illig, Thomas; Iribarren, Carlos; A. Jensen, Richard; Kähönen, Mika; Min Kang, Hyun; Kathiresan, Sekar; J. Keating, Brendan; Khaw, Kay‐Tee; Kyoung Kim, Yun; H. Kim, Eric; Kivimäki, Mika; Klopp, Norman; Kolovou, Genovefa; Komulainen, Pirjo; S. Kooner, Jaspal; Kosova, Gülüm; M. Krauss, Ronald; Kuh, Diana; Kutalik, Zoltán; Kuusisto, Johanna; Kvaløy, Kirsti; A. Lakka, Timo; Lee, Sang; Lee, I‐Te; Lee, Wen‐Jane; Levy, Daniel; Li, Xiaohui; Liang, Kae-Woei; Lin, Honghuang; Li, Lin; Lindström, Jaana; Lobbens, Stéphane; Männistö, Satu; Müller, Gabriele; Müller‐Nurasyid, Martina; Mach, François; S. Markus, Hugh; Marouli, Eirini; I. McCarthy, Mark; A. McKenzie, Colin; Meneton, Pierre; Menni, Cristina; Metspalu, Andres; Mijatovic, Vladan; Moilanen, Leena; E. Montasser, May; D Morris, Andrew; C. Morrison, Alanna; Mulas, Antonella; Nagaraja, Ramaiah; Narisu, Narisu; Nikus, Kjell; J. O’Donnell, Christopher; F. O’Reilly, Paul; K. Ong, Ken; Paccaud, Fred; D. Palmer, Cameron; Parsa, Afshin; L. Pedersen, Nancy; W.J.H. Penninx, Brenda; Perola, Markus; Peters, Annette; Poulter, Neil; P. Pramstaller, Peter; M. Psaty, Bruce; Quertermous, Thomas; C Rao, Dabeeru; Rasheed, Asif; William Rayner, N.; Renström, Frida; Rettig, Rainer; Rice, Kenneth; Roberts, Robert; M. Rose, Lynda; Rossouw, Jacques; J. Samani, Nilesh; Sanna, Serena; Saramies, Jouko; Schunkert, Heribert; Sebért, Sylvain; H-H Sheu, Wayne; Shin, Young-Ah; Sim, Xueling; H. Smit, Johannes; V. Smith, Albert; X. Sosa, Maria; D. Spector, Tim; Stančáková, Alena; Stanton, Alice; Stirrups, Kathleen; M. Stringham, Heather; Sundström, Johan; J. Swift, Amy; Syvänen, Ann‐Christine; Shyong Tai, E; Tanaka, Toshiko; V. Tarasov, Kirill; Teumer, Alexander; Thorsteinsdottir, Unnur; D. Tobin, Martin; Tremoli, Elena; G. Uitterlinden, André; Uusitupa, Matti; Vaez, Ahmad; Vaidya, Dhananjay; M. van Duijn, Cornelia; P.A. van Iperen, Erik; S. Vasan, Ramachandran; C. Verwoert, Germaine; Virtamo, Jarmo; Vitart, Véronique; F. Voight, Benjamin; Vollenweider, Péter; Wagner, Aline; V. Wain, Louise; J. Wareham, Nicholas; Watkins, Hugh; B. Weder, Alan; Westra, Harm-Jan; Wilks, Rainford; Wilsgaard, Tom; F Wilson, James; Yin Wong, Tien; Yang, Tsun-Po; Yao, Jie; Yengo, Loïc; Zhang, Weihua; Hua Zhao, Jing; Zhu, Xiaofeng; Bovet, Pascal; S Cooper, Richard; L Mohlke, Karen; Saleheen, Danish; Lee, Jong‐Young; Elliott, Paul; J. Gierman, Hinco; J. Willer, Cristen; Franke, Lude; Kees Hovingh, G.; D. Taylor, Kent; Dedoussis, George; S. Sever, Peter; Wong, Andrew; Lind, Lars; L. Assimes, Themistocles; Njølstad, Inger; E. H. Schwarz, Peter; Langenberg, Claudia; Snieder, Harold; J. Caulfield, Mark; Melander, Olle; Laakso, Markku; Saltevo, Juha; Rauramaa, Rainer; Tuomilehto, Jaakko; Ingelsson, Erik; Lehtimäki, Terho; Hveem, Kristian; Palmas, Walter; März, Winfried; Kumari, Meena; Salomaa, Veikko; I. Chen, Yii‐Der; I. Rotter, Jerome; Froguel, Philippe; Järvelin, Marjo‐Riitta; G. Lakatta, Edward; Kuulasmaa, Kari; W. Franks, Paul; Hamsten, Anders; Wichmann, H-Erich; N A Palmer, Colin; Stefánsson, Kāri; M. Ridker, Paul; J. F. 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doi:10.1038/ng.3667

Public

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

Published in Nature Genetics • Sep 12, 2016

Authors:

Georg Ehret

Teresa Ferreira

Daniel I. Chasman

Abstract

To dissect the genetic architecture of blood pressure and assess effects on target organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry, and genotypes from an additional 140,886 individuals were used for validation. We identified 66 ...

Subject

Biology

Single-nucleotide polymorphism

Genome-wide association study

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