NRASQ61R Mutation-specific Immunohistochemistry Also Identifies the HRASQ61R Mutation in Medullary Thyroid Cancer and May Have a Role in Triaging Genetic Testing for MEN2.

J, Reagh; M, Bullock; J, Andrici; J, Turchini; L, Sioson; A, Clarkson; N, Watson; A, Sheen; G, Lim; L, Delbridge; S, Sidhu; M, Sywak; A, Aniss; P, Shepherd; D, Ng; P, Oei; M, Field; D, Learoyd; BG, Robinson; RJ, Clifton-Bligh; AJ, Gill

doi:10.1097/pas.0000000000000740

Public

NRASQ61R Mutation-specific Immunohistochemistry Also Identifies the HRASQ61R Mutation in Medullary Thyroid Cancer and May Have a Role in Triaging Genetic Testing for MEN2.

Shared by NobleBlocks on Jan 1, 2017 • 12:00 AM UTC

Authors:

Reagh J

Bullock M

Andrici J

Abstract

A quarter of patients with medullary thyroid carcinoma (MTC) have germline mutations in the RET proto-oncogene indicating MEN2. Therefore genetic testing is recommended for all patients presenting with MTC. Approximately 40% of MTCs have somatic RET mutations. Somatic mutations in the RAS genes are ...

Discussions