Mutational signatures of ionizing radiation in second malignancies

Behjati, Sam; Gundem, Gunes; C. Wedge, David; D. Roberts, Nicola; Tarpey, Patrick; L. Cooke, Susanna; Van Loo, Peter; B. Alexandrov, Ludmil; Ramakrishna, Manasa; Davies, Helen; Nik‐Zainal, Serena; Hardy, Claire; Latimer, Calli; Raine, Keiran; Stebbings, Lucy; Menzies, Andy; Jones, David; Shepherd, Rebecca; P. Butler, Adam; W. Teague, Jon; Jorgensen, Mette; Khatri, Bhavisha; Pillay, Nischalan; Shlien, Adam; Andrew Futreal, P.; Badie, Christophe; Prostate Group, ICGC; S. Cooper, Colin; A. Eeles, Rosalind; F. Easton, Douglas; S. Foster, Christopher; E. Neal, David; S. Brewer, Daniel; C. Hamdy, Freddie; Lu, Yong‐Jie; G. Lynch, Andy; E. Massi, Charlie; Ng, Chi‐Fai; C. Whitaker, Hayley; Yu, Yongwei; Zhang, Hongwei; Bancroft, Elizabeth; M. Berney, Daniel; Camacho, Niedzica; Corbishley, Cathy; Dadaev, Tokhir; M. Dennis, Nening; Dudderidge, Tim; E. Edwards, Sandra; Fisher, Cyril; Ghori, Jilur; J. Gnanapragasam, Vincent; Greenman, Christopher; Hawkins, Steve; Hazell, Steven; Howat, Will; Karászi, Katalin; Kay, Jonathan; Kote‐Jarai, Zsofia; Kremeyer, Bárbara; Kumar, Pardeep; Lambert, Adam; Leongamornlert, Daniel; Livni, Naomi; J. Luxton, Hayley; Matthews, Lucy; Mayer, Erik; Merson, Susan; Nicol, David; Ogden, Christopher; O’Meara, Sarah; Pelvender, Gill; Shah, Nimish; Tavaré, Simon; Thomas, Sarah; Thompson, Alan; Verrill, Clare; Y. Warren, Anne; Zamora, Jorge; McDermott, Ultan; Steven Bova, G.; L. Richardson, Andrea; M. Flanagan, Adrienne; R. Stratton, Michael; J. Campbell, Peter

doi:10.1038/ncomms12605

Public

Mutational signatures of ionizing radiation in second malignancies

Published in Nature Communications • Sep 12, 2016

Authors:

Sam Behjati

Gunes Gundem

David C. Wedge

Abstract

Ionizing radiation is a potent carcinogen, inducing cancer through DNA damage. The signatures of mutations arising in human tissues following in vivo exposure to ionizing radiation have not been documented. Here, we searched for signatures of ionizing radiation in 12 radiation-associated second mali...

Subject

Ionizing radiation

Biology

Somatic cell

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