Romosozumab Treatment in Postmenopausal Women with Osteoporosis

Cosman, Felicia; B. Crittenden, Daria; D. Adachi, Jonathan; Binkley, Neil; J. Czerwiński, E.; Ferrari, Serge; C. Hofbauer, Lorenz; Lau, Edith; Michael Lewiecki, E.; Miyauchi, Akimitsu; A. F. Zerbini, Cristiano; E. Milmont, Cassandra; Chen, Li; Maddox, Judy; Meisner, Paul; Libanati, Cesar; Grauer, Andreas

doi:10.1056/nejmoa1607948

Public

Romosozumab Treatment in Postmenopausal Women with Osteoporosis

Published in New England Journal of Medicine • Sep 18, 2016

Authors:

Felicia Cosman

Daria B. Crittenden

Jonathan D. Adachi

Abstract

BACKGROUND: Romosozumab, a monoclonal antibody that binds sclerostin, increases bone formation and decreases bone resorption. METHODS: We enrolled 7180 postmenopausal women who had a T score of -2.5 to -3.5 at the total hip or femoral neck. Patients were randomly assigned to receive subcutaneous inj...

Subject

Medicine

Osteoporosis

Postmenopausal women

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