Genetic Determinants of Cisplatin Resistance in Patients With Advanced Germ Cell Tumors.

A, Bagrodia; BH, Lee; W, Lee; EK, Cha; JP, Sfakianos; G, Iyer; EJ, Pietzak; SP, Gao; EC, Zabor; I, Ostrovnaya; SD, Kaffenberger; A, Syed; ME, Arcila; RS, Chaganti; R, Kundra; J, Eng; J, Hreiki; V, Vacic; K, Arora; DM, Oschwald; MF, Berger; DF, Bajorin; MS, Bains; N, Schultz; VE, Reuter; J, Sheinfeld; GJ, Bosl; HA, Al-Ahmadie; DB, Solit; DR, Feldman

doi:10.1200/jco.2016.68.7798

Public

Genetic Determinants of Cisplatin Resistance in Patients With Advanced Germ Cell Tumors.

Shared by NobleBlocks on Sep 30, 2016 • 12:00 AM UTC

Authors:

Bagrodia A

Lee BH

Lee W

Abstract

Purpose Owing to its exquisite chemotherapy sensitivity, most patients with metastatic germ cell tumors (GCTs) are cured with cisplatin-based chemotherapy. However, up to 30% of patients with advanced GCT exhibit cisplatin resistance, which requires intensive salvage treatment, and have a 50% risk o...

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