Inhibition of the Nuclear Export Receptor XPO1 as a Therapeutic Target for Platinum-Resistant Ovarian Cancer

Chen, Ying; Catalina Camacho, Sandra; Silvers, Thomas; R. Abdul Razak, Albiruni; Gabrail, Nashat; F. Gerecitano, John; Kalir, Eva; Pereira, Elena; R. Evans, Brad; J. Ramus, Susan; Huang, Fei; Priedigkeit, Nolan; Rodríguez, Estefanía; Donovan, Michael; M. Khan, Faisal; Kalir, Tamara; Sebra, Robert; Uzilov, Andrew; Chen, Rong; Sinha, Rileen; Halpert, Richard; Billaud, Jean-Noël; Shacham, Sharon; McCauley, Dilara; Landesman, Yosef; Rashal, Tami; Kauffman, Michael; Raza Mirza, Mansoor; Mau‐Sørensen, Morten; Dottino, Peter; A. Martignetti, John

doi:10.1158/1078-0432.ccr-16-1333

Public

Inhibition of the Nuclear Export Receptor XPO1 as a Therapeutic Target for Platinum-Resistant Ovarian Cancer

Published in Clinical Cancer Research • Sep 20, 2016

Authors:

Ying Chen

Sandra Catalina Camacho

Thomas Silvers

Abstract

Abstract Purpose: The high fatality-to-case ratio of ovarian cancer is directly related to platinum resistance. Exportin-1 (XPO1) is a nuclear exporter that mediates nuclear export of multiple tumor suppressors. We investigated possible clinicopathologic correlations of XPO1 expression levels and ev...

Subject

Ovarian cancer

Cancer research

Apoptosis

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