A Pharmacological Chaperone Molecule Induces Cancer Cell Death by Restoring Tertiary DNA Structures in Mutant hTERT Promoters

Kang, Hyun-Jin; Cui, Yunxi; Yin, Holly; Scheid, Amy; P.D. Hendricks, William; Schmidt, Jessica; Sekulić, Aleksandar; Kong, De‐Ming; M. Trent, Jeffrey; Gokhale, Vijay; Mao, Hanbin; H. Hurley, Laurence

doi:10.1021/jacs.6b07598

Public

A Pharmacological Chaperone Molecule Induces Cancer Cell Death by Restoring Tertiary DNA Structures in Mutant hTERT Promoters

Published in Journal of the American Chemical Society • Sep 19, 2016

Authors:

Hyun-Jin Kang

Yunxi Cui

Holly Yin

Abstract

Activation of human telomerase reverse transcriptase (hTERT) is necessary for limitless replication in tumorigenesis. Whereas hTERT is transcriptionally silenced in normal cells, most tumor cells reactivate hTERT expression by alleviating transcriptional repression through diverse genetic and epigen...

Subject

Telomerase reverse transcriptase

Telomerase

Promoter

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