A Mechanosensor Mechanism Controls the G-Quadruplex/i-Motif Molecular Switch in the <i>MYC</i> Promoter NHE III<sub>1</sub>

Sutherland, Caleb; Cui, Yunxi; Mao, Hanbin; H. Hurley, Laurence

doi:10.1021/jacs.6b09196

Public

A Mechanosensor Mechanism Controls the G-Quadruplex/i-Motif Molecular Switch in the MYC Promoter NHE III1

Published in Journal of the American Chemical Society • Sep 26, 2016

Authors:

Caleb Sutherland

Yunxi Cui

Hanbin Mao

Abstract

MYC is overexpressed in many different cancer types and is an intensively studied oncogene because of its contributions to tumorigenesis. The regulation of MYC is complex, and the NHE III 1 and FUSE elements rely upon noncanonical DNA structures and transcriptionally induced negative superhelicity. ...

Subject

Chemistry

Nucleolin

G-quadruplex

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