An extended genotyping framework for Salmonella enterica serovar Typhi, the cause of human typhoid

K. Wong, Vanessa; Baker, Stephen; R. Connor, Thomas; Pickard, Derek; J. Page, Andrew; Dave, Jayshree; Murphy, Niamh; Holliman, Richard; Sefton, Armine; Millar, Michael; A. Dyson, Zoe; Dougan, Gordon; E. Holt, Kathryn; Typhoid Consortium, International; Parkhill, Julian; A. Feasey, Nicholas; A. Kingsley, Robert; R. Thomson, Nicholas; A. Keane, Jacqueline; Xavier Weill, François-; Le Hello, Simon; Hawkey, Jane; J. Edwards, David; R. Harris, Simon; K. Cain, Amy; Hadfield, James; J. Hart, Peter; Tran Vu Thieu, Nga; J. Klemm, Elizabeth; F. Breiman, Robert; H. Watson, Conall; John Edmunds, W.; Kariuki, Samuel; A. Gordon, Melita; S. Heyderman, Robert; Okoro, Chinyere; Jacobs, Jan; Lunguya, Octavie; Msefula, Chisomo; A. Chabalgoity, Jose; Kama, Mike; Jenkins, Kylie; Dutta, Shanta; Marks, Florian; Campos, Josefina; Thompson, Corinne; Obaro, Stephen; A. MacLennan, Calman; Dolecek, Christiane; H. Keddy, Karen; M. Smith, Anthony; M. Parry, Christopher; Karkey, Abhilasha; Dongol, Sabina; Basnyat, Buddha; Arjyal, Amit; Kim Mulholland, E.; I. Campbell, James; Dufour, Muriel; Bandaranayake, Don; N. Toleafoa, Take; Pravin Singh, Shalini; Hatta, Mochammad; N. Newton, Paul; Dance, David; Davong, Viengmon; S. Onsare, Robert; Isaia, Lupeoletalalelei; Thwaites, Guy; Wijedoru, Lalith; A. Crump, John; De Pinna, Elizabeth; Nair, Satheesh; J. Nilles, Eric; Pham Thanh, Duy; Turner, Paul; Soeng, Sona; Valcanis, Mary; Powling, Joan; Dimovski, Karolina; Hogg, Geoff; Farrar, Jeremy; E. Mather, Alison; Amos, Ben

doi:10.1038/ncomms12827

Public

An extended genotyping framework for Salmonella enterica serovar Typhi, the cause of human typhoid

Shared by NobleBlocks on Oct 5, 2016 • 12:00 AM UTC

Authors:

Vanessa K. Wong

Stephen Baker

Thomas R. Connor

Abstract

Abstract The population of Salmonella enterica serovar Typhi ( S. Typhi), the causative agent of typhoid fever, exhibits limited DNA sequence variation, which complicates efforts to rationally discriminate individual isolates. Here we utilize data from whole-genome sequences (WGS) of nearly 2,000 is...

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