An extended genotyping framework for Salmonella enterica serovar Typhi, the cause of human typhoid

Wong, Vanessa; Baker, Stephen; R. Connor, Thomas; Pickard, Derek; J. Page, Andrew; Dave, J.; Murphy, Niamh; Holliman, Richard; Sefton, Armine; Millar, Michael; A. Dyson, Zoe; Dougan, Gordon; E. Holt, Kathryn; Parkhill, Julian; Feasey, Nicholas; A. Kingsley, Robert; R. Thomson, Nicholas; A. Keane, Jacqueline; Weill, François‐Xavier; Le Hello, Simon; Hawkey, Jane; Edwards, David; R. Harris, Simon; K. Cain, Amy; Hadfield, James; Hart, Peter; Tran Vu Thieu, Nga; J. Klemm, Elizabeth; F. Breiman, Robert; Watson, Conall; John Edmunds, W.; Kariuki, Samuel; A. Gordon, Melita; S. Heyderman, Robert; K. Okoro, Chinyere; Jacobs, Jan; Lunguya, Octavie; Msefula, Chisomo; A. Chabalgoity, José; Kama, Mike; Jenkins, Kylie; Dutta, Shanta; Marks, Florian; Campos, Josefina; N. Thompson, Corinne; Obaro, Stephen; A. MacLennan, Calman; Dolecek, Christiane; H. Keddy, Karen; M. Smith, Anthony; M. Parry, Christopher; Karkey, Abhilasha; Dongol, Sabina; Basnyat, Buddha; Arjyal, Amit; Mulholland, Kim; I. Campbell, James; Dufour, Muriel; Bandaranayake, Don; N. Toleafoa, Take; Singh, Shalini; Hatta, Mochammad; N. Newton, Paul; A. B. Dance, David; Davong, Viengmon; Onsaŕe, Robert; Isaia, Lupeoletalalelei; Thwaites, Guy; Wijedoru, Lalith; A. Crump, John; de Pinna, Elizabeth; Nair, Satheesh; J. Nilles, Eric; Pham Thanh, Duy; Turner, Paul; Soeng, Sona; Valcanis, Mary; Powling, Joan; Dimovski, Karolina; Hogg, Geoff; Farrar, Jeremy; E. Mather, Alison; Amos, Ben

doi:10.1038/ncomms12827

Public

An extended genotyping framework for Salmonella enterica serovar Typhi, the cause of human typhoid

Published in Nature Communications • Oct 5, 2016

Authors:

Vanessa Wong

Stephen Baker

Thomas R. Connor

Abstract

The population of Salmonella enterica serovar Typhi (S. Typhi), the causative agent of typhoid fever, exhibits limited DNA sequence variation, which complicates efforts to rationally discriminate individual isolates. Here we utilize data from whole-genome sequences (WGS) of nearly 2,000 isolates sou...

Subject

Salmonella typhi

Typhoid fever

Genotyping

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