Cerebrospinal Fluid Aβ42/40 Corresponds Better than Aβ42 to Amyloid PET in Alzheimer’s Disease

Lewczuk, Piotr; Matzen, Anja; Blennow, Kaj; Parnetti, Lucilla; Luís Molinuevo, José; Eusebi, Paolo; Kornhuber, Johannes; C. Morris, John; M. Fagan, Anne

doi:10.3233/jad-160722

Public

Cerebrospinal Fluid Aβ42/40 Corresponds Better than Aβ42 to Amyloid PET in Alzheimer’s Disease

Published in Journal of Alzheimer s Disease • Oct 14, 2016

Authors:

Piotr Lewczuk

Anja Matzen

Kaj Blennow

Abstract

BACKGROUND: Decreased concentrations of amyloid-β 1-42 (Aβ42) in cerebrospinal fluid (CSF) and increased retention of Aβ tracers in the brain on positron emission tomography (PET) are considered the earliest biomarkers of Alzheimer's disease (AD). However, a proportion of cases show discrepancies be...

Subject

Cerebrospinal fluid

Amyloid β

Amyloid (mycology)

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