Favipiravir Pharmacokinetics in Nonhuman Primates and Insights for Future Efficacy Studies of Hemorrhagic Fever Viruses

Madelain, Vincent; Guedj, Jérémie; Mentré, France; Huyen Tram Nguyen, Thi; Jacquot, Frédéric; Oestereich, Lisa; Kadota, Takumi; Yamada, Koichi; Taburet, Anne‐Marie; de Lamballerie, Xavier; Raoul, Hervé

doi:10.1128/aac.01305-16

Public

Favipiravir Pharmacokinetics in Nonhuman Primates and Insights for Future Efficacy Studies of Hemorrhagic Fever Viruses

Published in Antimicrobial Agents and Chemotherapy • Oct 11, 2016

Authors:

Vincent Madelain

Jérémie Guedj

France Mentré

Abstract

ABSTRACT Favipiravir is an RNA polymerase inhibitor that showed strong antiviral efficacy in vitro and in small-animal models of several viruses responsible for hemorrhagic fever (HF), including Ebola virus. The aim of this work was to characterize the complex pharmacokinetics of favipiravir in nonh...

Subject

Favipiravir

Pharmacokinetics

Marburg virus

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