<i>IDH2</i> Mutations Define a Unique Subtype of Breast Cancer with Altered Nuclear Polarity

Chiang, Sarah; Weigelt, Britta; Wen, Huei‐Chi; Pareja, Fresia; Raghavendra, Ashwini; G. Martelotto, Luciano; A. Burke, Kathleen; Basili, Thais; Li, Anqi; C. Geyer, Felipe; Piscuoglio, Salvatore; K.Y. Ng, Charlotte; A. Jungbluth, Achim; Balß, Jörg; Pusch, Stefan; M. Baker, Gabrielle; Cole, Kimberly; von Deimling, Andreas; M. Batten, Julie; D. Marotti, Jonathan; Soh, Hwei-Choo; L. McCalip, Benjamin; Serrano, Jonathan; S. Lim, Raymond; P. Siziopikou, Kalliopi; Lu, Song; Liu, Xiaolong; Hammour, Tarek; Brogi, Edi; Snuderl, Matija; John Iafrate, A.; S. Reis‐Filho, Jorge; J. Schnitt, Stuart

doi:10.1158/0008-5472.can-16-0298

Public

IDH2 Mutations Define a Unique Subtype of Breast Cancer with Altered Nuclear Polarity

Published in Cancer Research • Oct 20, 2016

Authors:

Sarah Chiang

Britta Weigelt

Huei‐Chi Wen

Abstract

Solid papillary carcinoma with reverse polarity (SPCRP) is a rare breast cancer subtype with an obscure etiology. In this study, we sought to describe its unique histopathologic features and to identify the genetic alterations that underpin SPCRP using massively parallel whole-exome and targeted seq...

Subject

IDH2

Biology

Breast cancer

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