Molecular profiling of advanced solid tumors and patient outcomes with genotype-matched clinical trials: the Princess Margaret IMPACT/COMPACT trial

Stockley, Tracy; M. Oza, Amit; K. Berman, Hal; B. Leighl, Natasha; J. Knox, Jennifer; A. Shepherd, Frances; X. Chen, Eric; K. Krzyzanowska, Monika; C. Dhani, Neesha; M. Joshua, Anthony; Tsao, Ming‐Sound; Serra, Stefano; Clarke, Blaise; H. A. Roehrl, Michael; Zhang, Tong; A. Sukhai, Mahadeo; Califaretti, Nadia; Trinkaus, Mateya; Shaw, Patricia; van der Kwast, Theodorus; Wang, Lisa; Virtanen, Carl; H. Kim, Raymond; R. Abdul Razak, Albiruni; R. Hansen, Aaron; Yu, Celeste; J. Pugh, Trevor; Kamel‐Reid, Suzanne; L. Siu, Lillian; L. Bédard, Philippe

doi:10.1186/s13073-016-0364-2

Public

Molecular profiling of advanced solid tumors and patient outcomes with genotype-matched clinical trials: the Princess Margaret IMPACT/COMPACT trial

Published in Genome Medicine • Oct 25, 2016

Authors:

Tracy Stockley

Amit M. Oza

Hal K. Berman

Abstract

BACKGROUND: The clinical utility of molecular profiling of tumor tissue to guide treatment of patients with advanced solid tumors is unknown. Our objectives were to evaluate the frequency of genomic alterations, clinical "actionability" of somatic variants, enrollment in mutation-targeted or other c...

Subject

Profiling (computer programming)

Genotype

Medicine

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