Sodium butyrate activates NRF2 to ameliorate diabetic nephropathy possibly via inhibition of HDAC

Dong, Wenpeng; Jia, Ye; Liu, Xiuxia; Zhang, Huan; Li, Tie; Huang, Wenlin; Chen, Xudong; Wang, Fuchun; Sun, Weixia; Wu, Hao

doi:10.1530/joe-16-0322

Public

Sodium butyrate activates NRF2 to ameliorate diabetic nephropathy possibly via inhibition of HDAC

Published in Journal of Endocrinology • Oct 31, 2016

Authors:

Wenpeng Dong

Ye Jia

Xiuxia Liu

Abstract

Oxidative stress contributes to the pathogenesis of diabetic nephropathy (DN). Nuclear factor erythroid 2-related factor 2 (NRF2) plays a key role in cellular defense against oxidative stress. NRF2 activators have shown promising preventive effects on DN. Sodium butyrate (NaB) is a known activator o...

Subject

Diabetic nephropathy

Oxidative stress

Endocrinology

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