The Master Neural Transcription Factor BRN2 Is an Androgen Receptor–Suppressed Driver of Neuroendocrine Differentiation in Prostate Cancer

L. Bishop, Jennifer; Thaper, Daksh; Vahid, Sepideh; Davies, Alastair; Ketola, Kirsi; Kuruma, Hidetoshi; Jama, Randy; Mun Nip, Ka; Angeles, Arkhjamil; Johnson, Fraser; W. Wyatt, Alexander; Fazli, Ladan; E. Gleave, Martin; Lin, Dong; A. Rubin, Mark; C. Collins, Colin; Wang, Yuzhuo; Beltran, Himisha; Zoubeidi, Amina

doi:10.1158/2159-8290.cd-15-1263

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The Master Neural Transcription Factor BRN2 Is an Androgen Receptor–Suppressed Driver of Neuroendocrine Differentiation in Prostate Cancer

Shared by NobleBlocks on Jan 1, 2017 • 12:00 AM UTC

Authors:

Jennifer L. Bishop

Daksh Thaper

Sepideh Vahid

Abstract

Abstract Mechanisms controlling the emergence of lethal neuroendocrine prostate cancer (NEPC), especially those that are consequences of treatment-induced suppression of the androgen receptor (AR), remain elusive. Using a unique model of AR pathway inhibitor–resistant prostate cancer, we identified ...

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