Altered DNA Methylation of Long Noncoding RNA <i>H19</i> in Calcific Aortic Valve Disease Promotes Mineralization by Silencing <i>NOTCH1</i>

Hadji, Fayez; Boulanger, Marie‐Chloé; Guay, Simon‐Pierre; Gaudreault, Nathalie; Amellah, Soumiya; Mkannez, Guada; Bouchareb, Rihab; Tremblay Marchand, Joël; Jalloul Nsaibia, Mohamed; Guauque-Olarte, Sandra; Pîbarot, Philippe; Bouchard, Luigi; Bossé, Yohan; Mathieu, Patrick

doi:10.1161/circulationaha.116.023116

Public

Altered DNA Methylation of Long Noncoding RNA H19 in Calcific Aortic Valve Disease Promotes Mineralization by Silencing NOTCH1

Published in Circulation • Oct 28, 2016

Authors:

Fayez Hadji

Marie‐Chloé Boulanger

Simon‐Pierre Guay

Abstract

BACKGROUND: Calcific aortic valve disease is characterized by an abnormal mineralization of the aortic valve. Osteogenic activity in the aortic valve is under the control of NOTCH1, which regulates the expression of key pro-osteogenic genes such as RUNX2 and BMP2. Long noncoding RNAs (lncRNAs) may r...

Subject

Medicine

DNA methylation

Gene silencing

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