Does Piperacillin-Tazobactam Increase the Risk of Nephrotoxicity when Used with Vancomycin: A Meta-Analysis of Observational Trials

K. Mellen, Chadwick; E. Ryba, Jennifer; P. Rindone, Joseph

doi:10.2174/1574886311666161024164859

Public

Does Piperacillin-Tazobactam Increase the Risk of Nephrotoxicity when Used with Vancomycin: A Meta-Analysis of Observational Trials

Published in Current Drug Safety • Nov 3, 2016

Authors:

Chadwick K. Mellen

Jennifer E. Ryba

Joseph P. Rindone

Abstract

BACKGROUND: Observational studies have suggested an increased risk of nephrotoxicity when piperacillin-tazobactam is added to vancomycin, although the data are confliciting. OBJECTIVE: To perform a meta-analysis of identified studies to assess if adding piperacillin-tazobactam to vancomycin increase...

Subject

Medicine

Piperacillin/tazobactam

Vancomycin

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