Analysis of Pre-existing IgG and IgM Antibodies against Polyethylene Glycol (PEG) in the General Population

Yang, Qi; M. Jacobs, Timothy; McCallen, Justin; T. Moore, Dominic; T. Huckaby, Justin; Edelstein, Jasmine; K. Lai, Samuel

doi:10.1021/acs.analchem.6b03437

Public

Analysis of Pre-existing IgG and IgM Antibodies against Polyethylene Glycol (PEG) in the General Population

Published in Analytical Chemistry • Nov 2, 2016

Authors:

Qi Yang

Timothy M. Jacobs

Justin McCallen

Abstract

Circulating antibodies (Ab) that specifically bind polyethylene glycol (PEG), a biocompatible polymer routinely used in protein and nanoparticle therapeutics, have been associated with reduced efficacy of and/or adverse reactions to therapeutics modified with or containing PEG. Unlike most antidrug ...

Subject

PEG ratio

Chemistry

Polyethylene glycol

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