A new role for oxidative stress in aging: The accelerated aging phenotype in Sod1− mice is correlated to increased cellular senescence

Zhang, Yiqiang; Unnikrishnan, Archana; S. Deepa, Sathyaseelan; Liu, Yuhong; Li, Yan; Ikeno, Yuji; Sosnowska, Danuta; Van Remmen, Holly; Richardson, Arlan

doi:10.1016/j.redox.2016.10.014

Public

A new role for oxidative stress in aging: The accelerated aging phenotype in Sod1− mice is correlated to increased cellular senescence

Published in Redox Biology • Nov 2, 2016

Authors:

Yiqiang Zhang

Archana Unnikrishnan

Sathyaseelan S. Deepa

Abstract

In contrast to other mouse models that are deficient in antioxidant enzymes, mice null for Cu/Zn-superoxide dismutase ( Sod1 −/ − mice) show a major decrease in lifespan and several accelerated aging phenotypes. The goal of this study was to determine if cell senescence might be a contributing facto...

Subject

Senescence

Oxidative stress

SOD1

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