The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease

J. Astle, William; Elding, Heather; Jiang, Tao; Allen, Dave; Ruklisa, Dace; Mann, Alice; G. Mead, Daniel; Bouman, Heleen; Riveros-Mckay, Fernando; Kostadima, Myrto; Lambourne, John; Sivapalaratnam, Suthesh; Downes, Kate; Kundu, Kousik; Bomba, Lorenzo; Berentsen, Kim; R. Bradley, John; C. Daugherty, Louise; Delaneau, Olivier; Freson, Kathleen; F. Garner, Stephen; Grassi, Luigi; A. Guerrero, José; Haimel, Matthias; M. Janssen‐Megens, Eva; Kaan, Anita; Kamat, Mihir; Kim, Bowon; Mandoli, Amit; Marchini, Jonathan; H.A. Martens, Joost; Meacham, Stuart; Mégy, Karyn; O’Connell, Jared; Petersen, R.; Sharifi, Nilofar; Sheard, Simon; R Staley, James; Tuna, Salih; van der Ent, Martijn; Walter, Klaudia; Wang, Shuang-Yin; Wheeler, Eleanor; P. Wilder, Steven; Iotchkova, Valentina; Moore, Carmel; Sambrook, Jennifer; G. Stunnenberg, Hendrik; Di Angelantonio, Emanuele; Kaptoge, Stephen; W. Kuijpers, Taco; Carrillo de Santa Pau, Enrique; Juan, David; Rico, Daniel; Valencia, Alfonso; Chen, Lu; Ge, Bing; Vasquez, Louella; Kwan, Tony; Garrido-Martín, Diego; Watt, Stephen; Yang, Ying; Guigó, Roderic; Beck, Stephan; S. Paul, Dirk; Pastinen, Tomi; Bujold, David; Bourque, Guillaume; Frontini, Mattia; Danesh, John; J. Roberts, David; H. Ouwehand, Willem; S. Butterworth, Adam; Soranzo, Nicole

doi:10.1016/j.cell.2016.10.042

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The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease

Published in Cell • Nov 1, 2016

Authors:

William J. Astle

Heather Elding

Tao Jiang

Abstract

Many common variants have been associated with hematological traits, but identification of causal genes and pathways has proven challenging. We performed a genome-wide association analysis in the UK Biobank and INTERVAL studies, testing 29.5 million genetic variants for association with 36 red cell,...

Subject

Biology

Genome-wide association study

Mendelian randomization

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