Arachidonic acid and lipoxin A4 attenuate alloxan-induced cytotoxicity to RIN5F cells in vitro and type 1 diabetes mellitus in vivo.

NKV, Gundala; VGM, Naidu; UN, Das

doi:10.1002/biof.1336

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Arachidonic acid and lipoxin A4 attenuate alloxan-induced cytotoxicity to RIN5F cells in vitro and type 1 diabetes mellitus in vivo.

Shared by NobleBlocks on Nov 15, 2016 • 12:00 AM UTC

Authors:

Gundala NKV

Naidu VGM

Das UN

Abstract

Objective We studied whether polyunsaturated fatty acids (PUFAs) can protect rat insulinoma (RIN5F) cells against alloxan-induced apoptosis in vitro and type 1 diabetes mellitus (type 1 DM) in vivo and if so, mechanism of this beneficial action.Material and methods In vitro study was conducted using...

Subject

Arachidonic acid

alloxan

Type 1 diabetes mellitus

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