Arachidonic acid and lipoxin A4 attenuate alloxan‐induced cytotoxicity to<scp>RIN5F</scp>cells<i>in vitro</i>and type 1 diabetes mellitus<i>in vivo</i>

K.V. Gundala, Naveen; Naidu, V.G.M.; N. Das, Undurti

doi:10.1002/biof.1336

Public

Arachidonic acid and lipoxin A4 attenuate alloxan‐induced cytotoxicity toRIN5Fcellsin vitroand type 1 diabetes mellitusin vivo

Published in BioFactors • Nov 15, 2016

Authors:

Naveen K.V. Gundala

V.G.M. Naidu

Undurti N. Das

Abstract

OBJECTIVE: We studied whether polyunsaturated fatty acids (PUFAs) can protect rat insulinoma (RIN5F) cells against alloxan-induced apoptosis in vitro and type 1 diabetes mellitus (type 1 DM) in vivo and if so, mechanism of this beneficial action. MATERIAL AND METHODS: In vitro study was conducted us...

Subject

Arachidonic acid

In vivo

In vitro

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