Effect of Evolocumab on Progression of Coronary Disease in Statin-Treated Patients

J. Nicholls, Stephen; Puri, Rishi; J. Anderson, Todd; M. Ballantyne, Christie; Cho, Leslie; J.P. Kastelein, John; Köenig, Wolfgang; Somaratne, Ransi; Kassahun, Helina; Yang, Jingyuan; M. Wasserman, Scott; C. Scott, Robert; Ungi, Imre; Podolec, Jakub; Oude Ophuis, Antonius; H. Cornel, Jan; Borgman, Marilyn; M. Brennan, Danielle; E. Nissen, Steven

doi:10.1001/jama.2016.16951

Public

Effect of Evolocumab on Progression of Coronary Disease in Statin-Treated Patients

Published in JAMA • Nov 15, 2016

Authors:

Stephen J. Nicholls

Rishi Puri

Todd J. Anderson

Abstract

Importance: Reducing levels of low-density lipoprotein cholesterol (LDL-C) with intensive statin therapy reduces progression of coronary atherosclerosis in proportion to achieved LDL-C levels. Proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitors produce incremental LDL-C lowering in stat...

Subject

Medicine

Evolocumab

Alirocumab

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