Blood–Brain-Barrier-Penetrating Albumin Nanoparticles for Biomimetic Drug Delivery via Albumin-Binding Protein Pathways for Antiglioma Therapy

Lin, Tingting; Zhao, Pengfei; Jiang, Yifan; Tang, Yisi; Jin, Hongyue; Pan, Zhenzhen; He, Huining; C. Yang, Victor; Huang, Yongzhuo

doi:10.1021/acsnano.6b04268

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Blood–Brain-Barrier-Penetrating Albumin Nanoparticles for Biomimetic Drug Delivery via Albumin-Binding Protein Pathways for Antiglioma Therapy

Published in ACS Nano • Nov 8, 2016

Authors:

Tingting Lin

Pengfei Zhao

Yifan Jiang

Abstract

Nutrient transporters have been explored for biomimetic delivery targeting the brain. The albumin-binding proteins (e.g., SPARC and gp60) are overexpressed in many tumors for transport of albumin as an amino acid and an energy source for fast-growing cancer cells. However, their application in brain...

Subject

Blood–brain barrier

Albumin

Drug delivery

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