Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

J.W. Arts, Rob; Novakovic, Boris; ter Horst, Rob; Carvalho, Agostinho; Bekkering, Siroon; Lachmandas, Ekta; Rodrigues, Fernando; Silvestre, Ricardo; Cheng, Shih‐Chin; Wang, Shuang-Yin; Habibi, Ehsan; G. Gonçalves, Luís; Mesquita, Inês; Cunha, Cristina; van Laarhoven, Arjan; L. van de Veerdonk, Frank; L. Williams, David; van der Meer, J.W.M.; Logie, Colin; O'neill, Luke; A. Dinarello, Charles; P. Riksen, Niels; van Crevel, Reinout; B. Clish, Clary; A. Notebaart, Richard; A. B. Joosten, Leo; G. Stunnenberg, Hendrik; J. Xavier, Ramnik; G. Netea, Mihai

doi:10.1016/j.cmet.2016.10.008

Public

Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

Published in Cell Metabolism • Nov 17, 2016

Authors:

Rob J.W. Arts

Boris Novakovic

Rob ter Horst

Abstract

Induction of trained immunity (innate immune memory) is mediated by activation of immune and metabolic pathways that result in epigenetic rewiring of cellular functional programs. Through network-level integration of transcriptomics and metabolomics data, we identify glycolysis, glutaminolysis, and ...

Subject

Glutaminolysis

Innate immune system

Biology

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