Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci

T. Jones, Gregory; Tromp, Gerard; Kuivaniemi, Helena; Gretarsdottir, Solveig; F. Baas, Annette; Giusti, Betti; Strauss, Ewa; N.G. van‘t Hof, Femke; R. Webb, Thomas; Erdman, Robert; D. Ritchie, Marylyn; R. Elmore, James; Verma, Anurag; Pendergrass, Sarah; J. Kullo, Iftikhar; Ye, Zi; L. Peissig, Peggy; Gottesman, Omri; S. Verma, Shefali; Malinowski, Jennifer; J. Rasmussen-Torvik, Laura; M. Borthwick, Kenneth; T. Smelser, Diane; R. Crosslin, David; de Andrade, Mariza; J. Ryer, Evan; A. McCarty, Catherine; P. Böttinger, Erwin; A. Pacheco, Jennifer; C. Crawford, Dana; S. Carrell, David; S. Gerhard, Glenn; P. Franklin, David; J. Carey, David; L. Phillips, Victoria; J.A. Williams, Michael; Wei, Wenhua; Blair, Ross; A. Hill, Andrew; M. Vasudevan, Thodor; R. Lewis, David; A. Thomson, Ian; Krysa, Jo; B. Hill, Geraldine; Roake, Justin; R. Merriman, Tony; Oszkinis, Grzegorz; Galora, Silvia; Saracini, Claudia; Abbate, Rosanna; Pulli, Raffaele; Pratesi, Carlo; Saratzis, Athanasios; R. Verissimo, Ana; Bumpstead, Suzannah; A. Badger, Stephen; E. Clough, Rachel; Cockerill, Gillian; Hafez, Hany; Julian A. Scott, D.; Simon Futers, T.; P.R. Romaine, Simon; Bridge, Katherine; J. Griffin, Kathryn; A. Bailey, Marc; Smith, Alberto; M. Thompson, Matthew; M. van Bockxmeer, Frank; E. Matthiasson, Stefan; Thorleifsson, Gudmar; Thorsteinsdottir, Unnur; D. Blankensteijn, Jan; A.W. Teijink, Joep; Wijmenga, Cisca; de Graaf, Jacqueline; A. Kiemeney, Lambertus; S. Lindholt, Jes; Hughes, Anne; T. Bradley, Declan; Stirrups, Kathleen; Golledge, Jonathan; E. Norman, Paul; T. Powell, Janet; E. Humphries, Steve; E. Hamby, Stephen; H. Goodall, Alison; P. Nelson, Christopher; Sakalihasan, Natzi; Courtois, Audrey; E. Ferrell, Robert; Eriksson, Per; Folkersen, Lasse; Franco-Cereceda, Anders; D. Eicher, John; D. Johnson, Andrew; Betsholtz, Christer; Ruusalepp, Arno; Franzén, Oscar; E. Schadt, Eric; L.M. Björkegren, Johan; Lipovich, Leonard; M. Drolet, Anne; L. Verhoeven, Eric; J. Zeebregts, Clark; H. Geelkerken, Robert; R. van Sambeek, Marc; M. van Sterkenburg, Steven; de Vries, Jean-Paul; Stefansson, Kari; R. Thompson, John; I.W. de Bakker, Paul; Deloukas, Panos; D. Sayers, Robert; C. Harrison, Seamus; M. van Rij, Andre; J. Samani, Nilesh; J. Bown, Matthew

doi:10.1161/circresaha.116.308765

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Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci

Shared by NobleBlocks on Jan 20, 2017 • 12:00 AM UTC

Authors:

Gregory T. Jones

Gerard Tromp

Helena Kuivaniemi

Abstract

Rationale: Abdominal aortic aneurysm (AAA) is a complex disease with both genetic and environmental risk factors. Together, 6 previously identified risk loci only explain a small proportion of the heritability of AAA. Objective: To identify additional AAA risk loci using data from all available geno...

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