Design and Development of Pd‐Catalyzed Aerobic N‐Demethylation Strategies for the Synthesis of Noroxymorphone in Continuous Flow Mode

Gutmann, Bernhard; Cantillo, David; Weigl, Ulrich; Phillip Cox, D.; Oliver Kappe, C.

doi:10.1002/ejoc.201601453

Public

Design and Development of Pd‐Catalyzed Aerobic N‐Demethylation Strategies for the Synthesis of Noroxymorphone in Continuous Flow Mode

Published in European Journal of Organic Chemistry • Nov 30, 2016

Authors:

Bernhard Gutmann

David Cantillo

Ulrich Weigl

Abstract

Strategies for the generation of noroxymorphone from 14‐hydroxymorphinone are presented. Noroxymorphone is the key intermediate in the synthesis of various opioid antagonists, including naloxone, naltrexone, and nalmefene, as well as mixed agonists‐antagonists such as nalbuphine. The transformation ...

Subject

Chemistry

Catalysis

Combinatorial chemistry

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