Whole-transcriptome sequencing identifies a distinct subtype of acute lymphoblastic leukemia with predominant genomic abnormalities of
                    <i>EP300</i>
                    and
                    <i>CREBBP</i>

Qian, Maoxiang; Zhang, Hui; Kow-Yin Kham, Shirley; Liu, Shuguang; Jiang, Chuang; Zhao, Xujie; Lu, Yi; Goodings, Charnise; Lin, Ting-Nien; Zhang, Ranran; Moriyama, Takaya; Yin, Zhaohong; Li, Zhenhua; Chong Quah, Thuan; Ariffin, Hany; Moy Tan, Ah; Shen, Shuhong; Bhojwani, Deepa; Hu, Shaoyan; Chen, Suning; Zheng, Huyong; Pui, Ching-Hon; Eng-Juh Yeoh, Allen; J. Yang, Jun

doi:10.1101/gr.209163.116

Public

Whole-transcriptome sequencing identifies a distinct subtype of acute lymphoblastic leukemia with predominant genomic abnormalities of EP300 and CREBBP

Shared by NobleBlocks on Nov 28, 2016 • 12:00 AM UTC

Authors:

Maoxiang Qian

Hui Zhang

Shirley Kow-Yin Kham

Abstract

Chromosomal translocations are a genomic hallmark of many hematologic malignancies. Often as initiating events, these structural abnormalities result in fusion proteins involving transcription factors important for hematopoietic differentiation and/or signaling molecules regulating cell proliferatio...

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