Global Deletion of TSPO Does Not Affect the Viability and Gene Expression Profile

Wang, Huaishan; Zhai, Kangle; Xue, Yingchao; Yang, Jia; Yang, Qi; Fu, Yi; Hu, Yu; Liu, Fang; Wang, Weiqing; Cui, Lianxian; Chen, Hui; Zhang, Jianmin; He, Wei

doi:10.1371/journal.pone.0167307

Public

Global Deletion of TSPO Does Not Affect the Viability and Gene Expression Profile

Published in PLoS ONE • Dec 1, 2016

Authors:

Huaishan Wang

Kangle Zhai

Yingchao Xue

Abstract

Translocator Protein (18kDa, TSPO) is a mitochondrial outer membrane transmembrane protein. Its expression is elevated during inflammation and injury. However, the function of TSPO in vivo is still controversial. Here, we constructed a TSPO global knockout (KO) mouse with a Cre-LoxP system that abol...

Subject

Translocator protein

Knockout mouse

Biology

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