PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study

F. Schmidt, Amand; I. Swerdlow, Daniel; V. Holmes, Michael; Patel, Riyaz; Fairhurst-Hunter, Zammy; M. Lyall, Donald; Pires Hartwig, Fernando; Lessa Horta, Bernardo; Hyppönen, Elina; Power, Christine; Moldovan, Max; Van Iperen, Erik; Kees Hovingh, G.; Demuth, Ilja; Norman, Kristina; Steinhagen‐Thiessen, Elisabeth; Demuth, Juri; Bertram, Lars; Liu, Tian; Coassin, Stefan; Willeit, Johann; Kiechl, Stefan; Willeit, Karin; Mason, Dan; Wright, John; Morris, Richard; Wanamethee, Goya; H. Whincup, Peter; Ben‐Shlomo, Yoav; McLachlan, Stela; F. Price, Jackie; Kivimäki, Mika; Welch, Catherine; Sánchez-Gálvez, Adelaida; Marques‐Vidal, Pedro; Nicolaides, Andrew; G. Panayiotou, Andrie; Charlotte Onland‐Moret, N.; T. van der Schouw, Yvonne; Matullo, Giuseppe; Fiorito, Giovanni; Guarrera, Simonetta; Sacerdote, Carlotta; J. Wareham, Nicholas; Langenberg, Claudia; A. Scott, Robert; Luan, Jian’an; Bobák, Martin; Malyutina, Sofia; Pająk, Andrzej; Kubínová, Růžena; Tamošiūnas, Abdonas; Pikhart, Hynek; Lotte N. Husemoen, Lise; Grarup, Niels; Pedersen, Oluf; Hansen, Torben; Linneberg, Allan; Starup Simonsen, Kenneth; A. Cooper, Jackie; E. Humphries, Steve; H. Brilliant, Murray; Kitchner, Terrie; Håkonarson, Håkon; Carrell, David; A. McCarty, Catherine; Lester Kirchner, H.; B. Larson, Eric; R. Crosslin, David; de Andrade, Mariza; M. Roden, Dan; C. Denny, Joshua; L. Carty, Cara; Hancock, Stephen; Attia, John; Holliday, Elizabeth; O’Donnell, Martin; Yusuf, Salim; Chong, Michael; Paré, Guillaume; van der Harst, Pim; Abdullah Said, M.; N. Eppinga, Ruben; Verweij, Niek; Snieder, Harold; Christen, Tim; O. Mook‐Kanamori, Dennis; Gustafsson, Stefan; Lind, Lars; Ingelsson, Erik; Pazoki, Raha; H. Franco, Oscar; Hofman, Albert; G. Uitterlinden, André; Dehghan, Abbas; Teumer, Alexander; E. Baumeister, Sebastian; Dörr, Marcus; M. Lerch, Markus; Völker, Uwe; Völzke, Henry; Ward, Joey; P. Pell, Jill; J. Smıth, Daniel; Meade, Tom; H. Maitland‐van der Zee, Anke; Baranova, E.V.; Young, Robin; Ford, Ian; Campbell, Archie; Padmanabhan, Sandosh; L. Bots, Michiel; E. Grobbee, Diederick; Froguel, Philippe; Thuillier, Dorothée; Balkau, Beverley; Bonnefond, Amélie; Cariou, Bertrand; Smart, Melissa; Bao, Yanchun; Kumari, Meena; Mahajan, Anubha; M. Ridker, Paul; I. Chasman, Daniel; P. Reiner, Alex; A. Lange, Leslie; D. Ritchie, Marylyn; W. Asselbergs, Folkert; Casas, Juan-Pablo; J. Keating, Brendan; Preiss, David; D. Hingorani, Aroon; Sattar, Naveed

doi:10.1016/s2213-8587(16)30396-5

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PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study

Published in The Lancet Diabetes & Endocrinology • Nov 28, 2016

Authors:

Amand F. Schmidt

Daniel I. Swerdlow

Michael V. Holmes

Abstract

BACKGROUND: Statin treatment and variants in the gene encoding HMG-CoA reductase are associated with reductions in both the concentration of LDL cholesterol and the risk of coronary heart disease, but also with modest hyperglycaemia, increased bodyweight, and modestly increased risk of type 2 diabet...

Subject

Medicine

Mendelian randomization

Type 2 diabetes

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