Crizanlizumab for the Prevention of Pain Crises in Sickle Cell Disease

I. Ataga, Kenneth; Kutlar, Abdullah; Kanter, Julie; Liles, Darla; Delfini Cançado, Rodolfo; Ricardo Friedrisch, João; H. Guthrie, Troy; Knight‐Madden, Jennifer; Álvarez, Ofelia; R. Gordeuk, Victor; Gualandro, Sandra; Colella, Marina; R. Smith, Wally; A. Rollins, Scott; W. Stocker, Jonathan; P. Rother, Russell

doi:10.1056/nejmoa1611770

Public

Crizanlizumab for the Prevention of Pain Crises in Sickle Cell Disease

Published in New England Journal of Medicine • Dec 3, 2016

Authors:

Kenneth I. Ataga

Abdullah Kutlar

Julie Kanter

Abstract

BACKGROUND: The up-regulation of P-selectin in endothelial cells and platelets contributes to the cell-cell interactions that are involved in the pathogenesis of vaso-occlusion and sickle cell-related pain crises. The safety and efficacy of crizanlizumab, an antibody against the adhesion molecule P-...

Subject

Medicine

Acute chest syndrome

Placebo

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