Genome-wide, high-content siRNA screening identifies the Alzheimer’s genetic risk factor FERMT2 as a major modulator of APP metabolism

Alzheimer’s Disease Neuroimaging Initiative, ADGC,; Chapuis, Julien; Flaig, Amandine; Grenier‐Boley, Benjamin; Eysert, Fanny; Pottiez, Virginie; Deloison, Gaspard; Vandeputte, Alexandre; Ayral, Anne‐Marie; Mendes, Tiago; Desai, Shruti; Goate, Alison; Kauwe, John; Leroux, Florence; Herlédan, Adrien; Demiautte, Florie; Bauer, Charlotte; Checler, Frédéric; C. Petersen, Ronald; Blennow, Kaj; Zetterberg, Henrik; Minthon, Lennart; M. Van Deerlin, Vivianna; Man-Yee Lee, Virginia; M. Shaw, Leslie; Q. Trojanowski, John; Albert, Marilyn; Moghekar, Abhay; M. O’Brien, Richard; R. Peskind, Elaine; Malmanche, Nicolas; D. Schellenberg, Gerard; Dourlen, Pierre; Song, Ok‐Ryul; Cruchaga, Carlos; Amouyel, Philippe; Déprez, Benoît; Brodin, Priscille; Lambert, Jean‐Charles

doi:10.1007/s00401-016-1652-z

Public

Genome-wide, high-content siRNA screening identifies the Alzheimer’s genetic risk factor FERMT2 as a major modulator of APP metabolism

Published in Acta Neuropathologica • Dec 8, 2016

Authors:

ADGC, Alzheimer’s Disease Neuroimaging Initiative

Julien Chapuis

Amandine Flaig

Abstract

Genome-wide association studies (GWASs) have identified 19 susceptibility loci for Alzheimer's disease (AD). However, understanding how these genes are involved in the pathophysiology of AD is one of the main challenges of the "post-GWAS" era. At least 123 genes are located within the 19 susceptibil...

Subject

Biology

Genetics

Alzheimer's disease

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