Ph-like acute lymphoblastic leukemia: a high-risk subtype in adults

Jain, Nitin; G. Roberts, Kathryn; Jabbour, Elias; P. Patel, Keyur; Karina Eterovic, Agda; Chen, Ken; A. Zweidler‐McKay, Patrick; Lu, Xinyan; L. Fawcett, Gloria; A. Wang, Sa; Konoplev, Sergej; C. Harvey, Richard; Chen, I‐Ming; Payne-Turner, Debbie; Valentine, Marcus; A. Thomas, Deborah; Garcia‐Manero, Guillermo; Ravandi, Farhad; E. Cortes, Jörge; M. Kornblau, Steven; O’Brien, Susan; Pierce, Sherry; L. Jorgensen, Jeffrey; Shaw, Kenna; L. Willman, Cheryl; G. Mullighan, Charles; M. Kantarjian, Hagop; Konopleva, Marina

doi:10.1182/blood-2016-07-726588

Public

Ph-like acute lymphoblastic leukemia: a high-risk subtype in adults

Published in Blood • Dec 6, 2016

Authors:

Nitin Jain

Kathryn G. Roberts

Elias Jabbour

Abstract

Key Points Approximately 20% to 25% of adults with B-ALL have Ph-like ALL with increased frequency of Ph-like ALL in adults with Hispanic ethnicity. Adult patients with CRLF2+ ALL have poor long-term outcomes; novel strategies are needed to improve the outcomes.

Subject

Medicine

Lymphoblastic Leukemia

Young adult

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