Evidence of <i>Staphylococcus Aureus</i> Deformation, Proliferation, and Migration in Canaliculi of Live Cortical Bone in Murine Models of Osteomyelitis

L. de Mesy Bentley, Karen; P. Trombetta, Ryan; Nishitani, Kohei; N. Bello‐Irizarry, Sheila; Ninomiya, Mark; Zhang, Longze; Li Chung, Hung; L. McGrath, James; L. Daiss, John; A. Awad, Hani; L. Kates, Stephen; M. Schwarz, Edward

doi:10.1002/jbmr.3055

Public

Evidence of Staphylococcus Aureus Deformation, Proliferation, and Migration in Canaliculi of Live Cortical Bone in Murine Models of Osteomyelitis

Published in Journal of Bone and Mineral Research • Dec 8, 2016

Authors:

Karen L. de Mesy Bentley

Ryan P. Trombetta

Kohei Nishitani

Abstract

Although Staphylococcus aureus osteomyelitis is considered to be incurable, the major bacterial reservoir in live cortical bone has remained unknown. In addition to biofilm bacteria on necrotic tissue and implants, studies have implicated intracellular infection of osteoblasts and osteocytes as a me...

Subject

Bone canaliculus

Osteomyelitis

Staphylococcus aureus

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