A driver role for GABA metabolism in controlling stem and proliferative cell state through GHB production in glioma.

EA, El-Habr; LG, Dubois; F, Burel-Vandenbos; A, Bogeas; J, Lipecka; L, Turchi; FX, Lejeune; PL, Coehlo; T, Yamaki; BM, Wittmann; M, Fareh; E, Mahfoudhi; M, Janin; A, Narayanan; G, Morvan-Dubois; C, Schmitt; M, Verreault; L, Oliver; A, Sharif; J, Pallud; B, Devaux; S, Puget; P, Korkolopoulou; P, Varlet; C, Ottolenghi; I, Plo; V, Moura-Neto; T, Virolle; H, Chneiweiss; MP, Junier

doi:10.1007/s00401-016-1659-5

Public

A driver role for GABA metabolism in controlling stem and proliferative cell state through GHB production in glioma.

Shared by NobleBlocks on Dec 28, 2016 • 12:00 AM UTC

Authors:

El-Habr EA

Dubois LG

Burel-Vandenbos F

Abstract

Cell populations with differing proliferative, stem-like and tumorigenic states co-exist in most tumors and especially malignant gliomas. Whether metabolic variations can drive this heterogeneity by controlling dynamic changes in cell states is unknown. Metabolite profiling of human adult glioblasto...

Subject

GABA

Brain cancer

Valproate

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!