Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model

Tao, Shi‐Cong; Yuan, Ting; Zhang, Yue-Lei; Yin, Wenjing; Guo, Shang; Zhang, Changqing

doi:10.7150/thno.17133

Public

Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model

Published in Theranostics • Dec 28, 2016

Authors:

Shi‐Cong Tao

Ting Yuan

Yue-Lei Zhang

Abstract

OBJECTIVES: Osteoarthritis (OA) is the most common joint disease throughout the world. Exosomes derived from miR-140-5p-overexpressing synovial mesenchymal stem cells (SMSC-140s) may be effective in treating OA. We hypothesized that exosomes derived from SMSC-140 (SMSC-140-Exos) would enhance the pr...

Subject

Mesenchymal stem cell

Osteoarthritis

Microvesicles

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