Efficacy and effectiveness of an rVSV-vectored vaccine in preventing Ebola virus disease: final results from the Guinea ring vaccination, open-label, cluster-randomised trial (Ebola Ça Suffit!)

María Henao-Restrepo, Ana; Camacho, Anton; M. Longini, Ira; Watson, Conall; John Edmunds, W.; Egger, Matthias; W. Carroll, Miles; E. Dean, Natalie; Diatta, Ibrahima; Doumbia, Moussa; Draguez, Bertrand; Duraffour, Sophie; Enwere, Godwin; F. Grais, Rebecca; Günther, Stephan; Gsell, Pierre‐Stéphane; Hossmann, Stefanie; Viksmoen Watle, Sara; Kader Kondé, Mandy; Kéïta, Sakoba; Kone, Souleymane; Kuisma, Eewa; M. Levine, Myron; Mandal, Sema; Mauget, Thomas; Norheim, Gunnstein; Riveros, Ximena; Soumah, Aboubacar; Trelle, Sven; Vicari, Andrea; Røttingen, John-Arne; Kieny, Marie‐Paule

doi:10.1016/s0140-6736(16)32621-6

Public

Efficacy and effectiveness of an rVSV-vectored vaccine in preventing Ebola virus disease: final results from the Guinea ring vaccination, open-label, cluster-randomised trial (Ebola Ça Suffit!)

Published in The Lancet • Dec 23, 2016

Authors:

Ana María Henao-Restrepo

Anton Camacho

Ira M. Longini

Abstract

BACKGROUND: rVSV-ZEBOV is a recombinant, replication competent vesicular stomatitis virus-based candidate vaccine expressing a surface glycoprotein of Zaire Ebolavirus. We tested the effect of rVSV-ZEBOV in preventing Ebola virus disease in contacts and contacts of contacts of recently confirmed cas...

Subject

Ebola virus

Ebola vaccine

Sierra leone

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